Modeling the Interplay Between Tumor Volume Regression and Oxygenation in Uterine Cervical Cancer During Radiotherapy Treatment
A novel modeling approach of tumor growth and response to radiotherapy is presented and tested on cervical cancer patient data. A patient-specific mathematical model is developed to predict the evolution of cancer volume at a macroscopic scale, during fractionated external radiotherapy. The model provides estimates of the re-growth of the active portion of the tumor along with their impairment due to irradiation using the linear-quadratic model. At the same time, it accounts for the necrotic portion dynamics by means of an exponential decay to mimic the dead-cell reabsorption.